CD1D antibody
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Name
CD1D antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab01436
Tested Applications
ELISA, WB, IHC
Description
Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | CD1d molecule (CD1D) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 1E3 |
| Observed MW | 38-40 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P15813 |
| Gene ID | 912 |
| Alias | R3,CD1A,R3G1,Antigen-presenting glycoprotein CD1d |
| Background | Antibody anti-CD1D |
| Status | RUO |
| Note | Mol. Weight 38-40 kDa |
Background
CD1D is a key member of the CD1 family of glycoproteins, which are specialized antigen-presenting molecules. CD1 proteins are distinct from classical major histocompatibility complex (MHC) class I and II molecules in that they present lipid and glycolipid antigens, rather than peptide antigens, to T cells. CD1D is unique within the CD1 family because of its specialized role in presenting lipid antigens to natural killer T (NKT) cells, particularly the invariant NKT (iNKT) cells, which express a semi-invariant T cell receptor (TCR). This interaction is essential for initiating rapid immune responses against a variety of pathogens, as well as in immune regulation. CD1D is expressed predominantly on antigen-presenting cells (APCs), such as dendritic cells, macrophages, and B cells, but is also found on certain epithelial cells. Through its interaction with NKT cells, CD1D mediates a range of immune responses, including the production of cytokines that regulate the function of other immune cells, such as dendritic cells, natural killer (NK) cells, and conventional T cells. This makes CD1D important not only for pathogen defense but also for the regulation of inflammation, tolerance, and tumor immunity.
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