CD163 antibody
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935106861
info@markelab.com
name
CD163 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09771
tested applications
ELISA, WB, IHC, FC
Description
CD163 is a transmembrane protein which belongs to the scavenger receptor cysteine-rich(SRCR) superfamily. This protein is a scavenger receptor for the hemoglobin-haptoglobin complex and is a marker for monocytes and macrophages. Soluble CD163(sCD163), as a result of ectodomain shedding during inflammatory activation of macrophages, circulates in blood and has been suggested as a plasma/serum marker for macrophage activity.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD163 (CD163) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:300-1:1000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 140 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86VB7 |
| Alias | Scavenger receptor cysteine-rich type 1 protein M130,M130,MM130,SCARI1,Hemoglobin scavenger receptor |
| Background | Antibody anti-CD163 |
| Status | RUO |
| Note | Mol. Weight 140 kDa |
Descripción
CD163, also known as the hemoglobin scavenger receptor, is a transmembrane glycoprotein expressed primarily on the surface of monocytes and macrophages. Encoded by the CD163 gene on chromosome 12 in humans, CD163 functions as a receptor for the haptoglobin-hemoglobin (Hp-Hb) complex. It is critical in scavenging free hemoglobin (Hb) released during red blood cell breakdown, thus protecting tissues from oxidative damage and inflammation due to free hemoglobin. Additionally, CD163 is part of the cysteine-rich scavenger receptor family and plays an important role in immune modulation, inflammation resolution, and tissue remodeling. Through its function as an anti-inflammatory receptor, CD163 contributes to the regulation of immune responses, often acting as a “sensor” for inflammatory conditions. When inflammation is detected, CD163-expressing cells can trigger responses that help protect tissues, making this molecule an essential component in maintaining immune homeostasis and limiting excessive immune reactions.
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