anti- CD151 antibody

Background

CD151 is a cell-surface protein belonging to the tetraspanin family, a group of transmembrane proteins involved in cell signaling, adhesion, and migration. This protein, encoded by the CD151 gene, is expressed on a wide range of cell types, including epithelial cells, endothelial cells, platelets, and certain hematopoietic cells. CD151 is known to interact with various integrins—primarily integrins α3β1, α6β1, and α6β4—which are crucial for cellular adhesion to the extracellular matrix (ECM) and in forming stable cellular junctions. CD151 is a key player in numerous physiological processes, including wound healing, angiogenesis, hemostasis, and immune responses. Additionally, this protein has been implicated in various diseases, notably cancer metastasis, kidney disease, and platelet-related disorders. Given its integral role in cellular adhesion and signaling, CD151 is considered a therapeutic target in certain diseases.