CC2D1A antibody
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Description
Transcription factor that binds specifically to the DRE(dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses(By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | coiled-coil and C2 domain containing 1A (CC2D1A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 130 kDa, 104 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6P1N0 |
| Gene ID | 54862 |
| Alias | Coiled-coil and C2 domain-containing protein 1A,Akt kinase-interacting protein 1,Five prime repressor element under dual repression-binding protein 1 (FRE under dual repression-binding protein 1, Freud-1),Putative NF-kappa-B-activating protein 023N,CC2D1A,AKI1 |
| Background | Antibody anti-CC2D1A |
| Status | RUO |
| Note | Mol. Weight 130 kDa, 104 kDa |
Descripción
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