CASP8 antibody
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935106861
info@markelab.com
name
CASP8 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01294
tested applications
ELISA, IHC, WB,IF,IP
Description
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibody can recognize pro-and cleaved-caspase 8.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | caspase 8, apoptosis-related cysteine peptidase (CASP8) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:100-1:400; IF: 1:50-1:500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2C2 |
| Observed MW | 50-55 kDa, 25-32 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB,IF,IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q14790 |
| Alias | Caspase-8 (CASP-8),Apoptotic cysteine protease,Apoptotic protease Mch-5,CAP4,FADD-homologous ICE/ced-3-like protease,FADD-like ICE (FLICE),ICE-like apoptotic protease 5,MORT1-associated ced-3 homolog (MACH),Caspase-8 subunit p18,Caspase-8 subunit p10,CASP8,MCH5 |
| Background | Antibody anti-CASP8 |
| Status | RUO |
| Note | Mol. Weight 50-55 kDa, 25-32 kDa |
Descripción
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