CADM3 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
CADM3 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab01191
Tested Applications
ELISA, WB
Description
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions(By similarity).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | cell adhesion molecule 3 (CADM3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 38-50 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8N126 |
| Gene ID | 57863 |
| Alias | BIgR,NECL1,TSLL1,CMT2FF,IGSF4B,Necl-1,synCAM3,TSLC1-like protein 1,Nectin-like protein 1,Immunoglobulin superfamily member 4B,Brain immunoglobulin receptor |
| Background | Antibody anti-CADM3 |
| Status | RUO |
| Note | Mol. Weight 38-50 kDa |
Background
CADM3, also known as SynCAM3 or nectin-like molecule 1 (Necl-1), is a neural cell adhesion molecule critical for axon-dendrite interactions, synaptic formation, and neural development. It is highly expressed in the nervous system, particularly in the brain, where it mediates the formation and maintenance of synaptic connections. CADM3 plays a crucial role in axon guidance and fasciculation, processes that are essential for proper neural circuit assembly during development. It facilitates both homophilic and heterophilic interactions with other adhesion molecules, contributing to the establishment of synaptic specificity and organization. CADM3 interacts with intracellular scaffolding proteins and signaling pathways to regulate actin cytoskeletal dynamics and intracellular signaling. Mutations or altered expression of CADM3 have been associated with neurodevelopmental disorders and cognitive deficits, highlighting its importance in brain function. Structurally, CADM3 contains extracellular Ig-like domains responsible for its adhesive properties and intracellular domains that anchor to the cytoskeleton and signaling complexes. CADM3's functions extend beyond the nervous system, as it is also expressed in epithelial tissues, where it contributes to cellular polarity and adhesion. Its role in tumor suppression has been explored, with evidence suggesting that CADM3 downregulation enhances tumor cell invasiveness and metastasis.
Productos relacionados
Cell Adhesion Molecule 3 (CADM3) Antibody
CADM3 Antibody is a Rabbit Polyclonal antibody against CADM3. IGSF4B is a brain-specific protein related to the calcium-…
Ver producto
Cell Adhesion Molecule 3 (CADM3) Antibody
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see…
Ver producto
Cell Adhesion Molecule 3 (CADM3) Antibody
Cell Adhesion Molecule 3 Antibody is a Rabbit Polyclonal antibody against Cell Adhesion Molecule 3.…
Ver producto