C4(gamma chain) antibody

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935106861
info@markelab.com
name
C4(gamma chain) antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01112
tested applications
ELISA, WB, IHC

Documents del producto

Instrucciones
Descargar
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
complement component 4A(Rodgers blood group) (C4(gamma chain))
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1:2000-1:10000; IHC: 1:200-1:1000
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Clone ID
4A9
Observed MW
31 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Protein A+G purification
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P0C0L4
Gene ID
720
Alias
Complement C4-A,Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2,Complement C4 beta chain,Complement C4-A alpha chain,C4a anaphylatoxin,C4b-A,C4d-A,Complement C4 gamma chain,C4A,CO4,CPAMD2
Background
Antibody anti-C4
Status
RUO
Note
Mol. Weight 31 kDa

Complement C4A (Chido/Rodgers blood group) is a component of the classical complement pathway, which plays a crucial role in immune defense and inflammation C4A is involved in the formation of the C3 convertase complex, which leads to the activation of the complement cascade, promoting opsonization, pathogen destruction, and inflammation The Chido and Rodgers antigens are variants of C4A that are of clinical interest due to their association with blood transfusion reactions and their use as markers in blood group systems Complement C4A, along with C4B, contributes to the body's ability to fight infections, clear immune complexes, and resolve inflammation Dysregulation of C4A has been implicated in autoimmune diseases, such as lupus, where complement activation exacerbates tissue damage and inflammation C4A also influences immune responses to cancer, where its role in immune complex clearance can impact tumor progression and metastasis Understanding C4A and its polymorphisms is crucial for improving clinical approaches to immune modulation and blood group testing

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C4(gamma chain) antibody | FNab01112