C4(alpha chain) antibody
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935106861
info@markelab.com
name
C4(alpha chain) antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01111
tested applications
ELISA, WB, IHC
Description
Complement C4, a component of the classical complement pathway, has an important role in innate immune function. C4 protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains (molecular wights 95, 78, and 31 kDa) prior to secretion. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. This antibody can recognize C4 precursor, C4 alpha chain, C4b, and C4d.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | complement component 4A(Rodgers blood group) (C4(alpha chain)) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000-1:6000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 95 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P0C0L4 |
| Gene ID | 720 |
| Alias | Complement C4-A,Acidic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2,Complement C4 beta chain,Complement C4-A alpha chain,C4a anaphylatoxin,C4b-A,C4d-A,Complement C4 gamma chain,C4A,CO4,CPAMD2 |
| Background | Antibody anti-C4 |
| Status | RUO |
| Note | Mol. Weight 95 kDa |
Descripción
Complement C4A (Chido/Rodgers blood group) is a component of the classical complement pathway, which plays a crucial role in immune defense and inflammation C4A is involved in the formation of the C3 convertase complex, which leads to the activation of the complement cascade, promoting opsonization, pathogen destruction, and inflammation The Chido and Rodgers antigens are variants of C4A that are of clinical interest due to their association with blood transfusion reactions and their use as markers in blood group systems Complement C4A, along with C4B, contributes to the body's ability to fight infections, clear immune complexes, and resolve inflammation Dysregulation of C4A has been implicated in autoimmune diseases, such as lupus, where complement activation exacerbates tissue damage and inflammation C4A also influences immune responses to cancer, where its role in immune complex clearance can impact tumor progression and metastasis Understanding C4A and its polymorphisms is crucial for improving clinical approaches to immune modulation and blood group testing
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