C3/C3b/C3c antibody

Este producto es parte de Complement C3
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935106861
info@markelab.com
name
C3/C3b/C3c antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01103
tested applications
ELISA, WB, IHC, IF

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
complement component 3 (C3/C3b/C3c)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1:1000-1:4000; IHC: 1:20-1:200; IF: 1:50-1:500
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Clone ID
8G4
Observed MW
115 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Protein A+G purification
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P01024
Alias
ASP,C3a,C3b,AHUS5,ARMD9,CPAMD1,HEL-S-62p,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
Background
Antibody anti-C3
Status
RUO
Note
Mol. Weight 115 kDa

Complement C3 is a central component of the complement system, an essential part of the innate immune response that aids in the clearance of pathogens and the regulation of inflammation C3 is involved in all three complement pathways (classical, alternative, and lectin), playing a critical role in immune defense by promoting opsonization, cell lysis, and inflammation activation Upon cleavage into C3a and C3b, C3a acts as an inflammatory mediator, and C3b binds to pathogens to mark them for destruction by phagocytes Complement C3 deficiency or dysfunction is associated with various autoimmune diseases, such as systemic lupus erythematosus (SLE), and with susceptibility to infections C3 is also involved in the regulation of adaptive immunity, influencing antibody production and T-cell responses Its role in inflammation, pathogen clearance, and immune system regulation highlights its importance in maintaining immune balance and tissue homeostasis

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