BCL2 antibody

Este producto es parte de BCL2 - BCL2 apoptosis regulator
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935106861
info@markelab.com
name
BCL2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00840
tested applications
ELISA, WB, IP, IHC

Description

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
B-cell CLL/lymphoma 2 (BCL2)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG2a
Clone ID
8A10
Observed MW
26 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Protein A+G purification
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IP, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P10415
Gene ID
596
Alias
Bcl-2,PPP1R50,B-Cell CLL/Lymphoma 2
Background
Antibody anti-BCL2
Status
RUO
Note
Mol. Weight 26 kDa

Descripción

BCL2 apoptosis regulator (BCL2) is a key anti-apoptotic protein that plays a central role in regulating cell survival by preventing mitochondrial-mediated apoptosis BCL2 functions by inhibiting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, thus preventing caspase activation and cell death It is highly expressed in various tissues, particularly in immune cells and neurons, where it protects against apoptosis and supports cell longevity Dysregulation of BCL2 expression has been associated with several diseases, including cancer, where its overexpression allows tumor cells to evade cell death, contributing to tumor progression and resistance to therapy BCL2 is also implicated in neurodegenerative diseases, where its dysfunction can lead to excessive neuronal death BCL2 interacts with other members of the Bcl-2 family, including pro-apoptotic proteins like BAX, to finely tune apoptotic signaling and maintain cellular homeostasis Its role in regulating apoptosis and survival pathways makes BCL2 a critical factor in development, aging, and disease management

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