BCL2 antibody
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Name
BCL2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00840
Tested Applications
ELISA, WB, IP, IHC
Description
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | B-cell CLL/lymphoma 2 (BCL2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 8A10 |
| Observed MW | 26 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P10415 |
| Gene ID | 596 |
| Alias | Bcl-2,PPP1R50,B-Cell CLL/Lymphoma 2 |
| Background | Antibody anti-BCL2 |
| Status | RUO |
| Note | Mol. Weight 26 kDa |
Background
BCL2 apoptosis regulator (BCL2) is a key anti-apoptotic protein that plays a central role in regulating cell survival by preventing mitochondrial-mediated apoptosis BCL2 functions by inhibiting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, thus preventing caspase activation and cell death It is highly expressed in various tissues, particularly in immune cells and neurons, where it protects against apoptosis and supports cell longevity Dysregulation of BCL2 expression has been associated with several diseases, including cancer, where its overexpression allows tumor cells to evade cell death, contributing to tumor progression and resistance to therapy BCL2 is also implicated in neurodegenerative diseases, where its dysfunction can lead to excessive neuronal death BCL2 interacts with other members of the Bcl-2 family, including pro-apoptotic proteins like BAX, to finely tune apoptotic signaling and maintain cellular homeostasis Its role in regulating apoptosis and survival pathways makes BCL2 a critical factor in development, aging, and disease management
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