BAX antibody
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Name
BAX antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00811
Tested Applications
ELISA, WB,IHC,IF
Description
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | BCL2-associated X protein (BAX) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:1000-1:10000; IHC: 1:400-1:1000; IF: 1:50-1:500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 5F4 |
| Observed MW | 21 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB,IHC,IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q07812 |
| Gene ID | 581 |
| Alias | BAX,BCL2L4,BCL2 associated X protein,Bcl-2-like protein 4,Bcl2-L-4 |
| Background | Antibody anti-BAX |
| Status | RUO |
| Note | Mol. Weight 21 kDa |
Background
BCL2 associated X, apoptosis regulator (BAX) is a pro-apoptotic protein that plays a critical role in mitochondrial-mediated apoptosis, a key process in regulating cell death BAX is activated in response to various stress signals, including DNA damage and oxidative stress, and it translocates to the mitochondria, where it promotes the release of cytochrome c, leading to the activation of caspases and cell death BAX functions as a counterpart to anti-apoptotic proteins like BCL2, which inhibit apoptosis BAX's activity is tightly regulated, as excessive activation can lead to uncontrolled cell death and tissue damage Its dysregulation has been implicated in several diseases, including cancer, where reduced BAX activity allows tumor cells to evade apoptosis, contributing to tumor progression and resistance to therapy BAX also has a role in regulating immune responses, particularly in T-cell development and survival, making it crucial for immune system homeostasis Additionally, BAX is involved in neurodegenerative diseases, where excessive cell death in neurons leads to conditions like Alzheimer's and Parkinson's
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