ANKRD11 antibody
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935106861
info@markelab.com
name
ANKRD11 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00405
tested applications
ELISA, WB
Description
ANKRD11, also named as ANCO1, may recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. This antibody is specific to ANKRD11. ANKRD11 exists 150-170 kDa isoform.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ankyrin repeat domain 11 (ANKRD11) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 160 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6UB99 |
| Gene ID | 29123 |
| Alias | ANCO-1,ANCO1,LZ16,T13 |
| Background | Antibody anti-ANKRD11 |
| Status | RUO |
| Note | Mol. Weight 160 kDa |
Descripción
ANKRD11 is a multifunctional protein that interacts with histone deacetylases (HDACs) to regulate histone acetylation, thereby influencing chromatin structure and gene expression. It plays a critical role in neural development, acting as a co-regulator of transcription factors that control neuronal differentiation and synaptic function. Mutations in ANKRD11 are linked to KBG syndrome, a rare neurodevelopmental disorder characterized by intellectual disability, distinct craniofacial features, and skeletal anomalies. ANKRD11 has also been implicated in autism spectrum disorders and cancer progression, where it contributes to altered cell growth, differentiation, and survival. Its role in epigenetic regulation and transcriptional modulation makes ANKRD11 essential for proper cellular function, particularly in the nervous system and during embryonic development.
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