AMH antibody
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935106861
info@markelab.com
name
AMH antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00359
tested applications
ELISA, WB, IHC
Description
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.The deduced protein sequence of the AMH monomer contains a 25 amino acid secretion specific signal peptide and a monomeric protein of 535 amino acids that, when glycosylated at two glycosylation sites, has a molecular weight of 65-70 kDa.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | anti-Mullerian hormone (AMH) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 65-70 kD |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P03971 |
| Gene ID | 268 |
| Alias | AMH,MIF |
| Background | Antibody anti-AMH |
| Status | RUO |
| Note | Mol. Weight 65-70 kDa |
Descripción
Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting factor (MIF), is a protein hormone that plays a critical role in the development of the reproductive system, particularly in males. It is produced by cells within the testes called Sertoli cells, as well as by granulosa cells in the ovaries of females. During fetal development in males, AMH is secreted by the Sertoli cells and functions to inhibit the development of the Müllerian ducts, which are precursor structures for female reproductive organs such as the fallopian tubes, uterus, and upper vagina. By suppressing the development of these Müllerian structures, AMH helps promote the formation of male reproductive organs, including the epididymis, vas deferens, and seminal vesicles. In females, AMH is also produced by granulosa cells within ovarian follicles, but its role is different. In females, AMH levels are highest during early follicular development and decline as follicles mature. AMH is involved in regulating the growth and development of ovarian follicles and has been used as a marker of ovarian reserve, which refers to the number and quality of a woman's remaining eggs
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