ALX1 antibody
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name
ALX1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00352
tested applications
ELISA, WB
Description
Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes(PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival(PubMed:20451171). May also induce epithelial to mesenchymal transition(EMT) through the expression of SNAI1(PubMed:23288509).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ALX homeobox 1 (ALX1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 37 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q15699 |
| Gene ID | 8092 |
| Alias | ALX1,CART1,FND3,HEL23 |
| Background | Antibody anti-ALX1 |
| Status | RUO |
| Note | Mol. Weight 37 kDa |
Descripción
ALX1 is a homeobox transcription factor that plays a critical role in embryonic development, particularly in craniofacial morphogenesis. ALX1 regulates gene expression involved in mesenchymal cell differentiation and skeletal development. Mutations in ALX1 are associated with frontonasal dysplasia (FND), a congenital disorder characterized by craniofacial anomalies such as cleft palate, wide nasal bridge, and abnormal eye positioning (hypertelorism). ALX1 is essential for the proper formation of facial structures during early development, as it influences neural crest cell migration and differentiation into facial mesenchyme. Beyond craniofacial development, ALX1 has been implicated in limb and organ patterning. Dysregulation of ALX1 may result in developmental abnormalities, highlighting its importance as a key regulator of embryogenesis. Recent studies suggest ALX1 may also be involved in tissue regeneration and mesenchymal stem cell maintenance, broadening its functional significance.
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ALX1 antibody
Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes(PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival(PubMed:20451171). May also induce epithelial to mesenchymal transition(EMT) through the expression of SNAI1(PubMed:23288509).
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