anti- ALDH7A1 antibody
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935106861
info@markelab.com
name
anti- ALDH7A1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00299
tested applications
ELISA, WB, IHC
Description
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldehyde dehydrogenase 7 family, member A1 |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P49419 |
| Gene ID | 501 |
| Alias | ALDH7A1,ATQ1 |
| Background | Antibody anti-ALDH7A1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ALDH7A1, also known as antiquitin, is a multifunctional enzyme involved in lysine catabolism and aldehyde detoxification. It catalyzes the oxidation of α-aminoadipic semialdehyde to α-aminoadipate, a key step in the lysine degradation pathway. Mutations in ALDH7A1 cause pyridoxine-dependent epilepsy (PDE), a rare inherited disorder characterized by seizures that are responsive to vitamin B6 (pyridoxine) supplementation. ALDH7A1 deficiency leads to the accumulation of toxic intermediates, such as α-aminoadipic semialdehyde, which interfere with neurotransmitter function and neuronal health. ALDH7A1 also plays a role in detoxifying aldehydes generated during lipid peroxidation and oxidative stress, protecting tissues from damage. Its expression in the liver, brain, and kidneys highlights its importance in amino acid metabolism, energy production, and cellular defense against aldehyde toxicity.
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