AKR7A2 antibody
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Description
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) (AKR7A2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 40 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O43488 |
| Gene ID | 8574 |
| Alias | AKR7A2,AFAR,AFAR1,AKR7 |
| Background | Antibody anti-AKR7A2 |
| Status | RUO |
| Note | Mol. Weight 40 kDa |
Descripción
AKR7A2 is a member of the aldo-keto reductase superfamily that plays a central role in detoxifying harmful aldehydes, including those generated from reactive oxygen species (ROS) and environmental toxins. It specifically reduces aflatoxin B1-dialdehyde, a highly toxic metabolite produced from aflatoxin exposure, into its less reactive alcohol form, protecting cells from aflatoxin-induced damage. AKR7A2 is highly expressed in the liver, kidneys, and gastrointestinal tract, where it safeguards against toxic metabolites arising from dietary toxins, such as aflatoxins, and endogenous lipid peroxidation products like 4-hydroxynonenal (4-HNE). It is also involved in detoxifying aldehydes produced during ethanol metabolism, linking it to alcohol-induced liver injury prevention. AKR7A2 has antioxidant properties that help maintain cellular redox balance under oxidative stress. Dysregulation of AKR7A2 can lead to increased susceptibility to aflatoxin-induced liver carcinogenesis, as inefficient detoxification exacerbates DNA damage and mutagenesis. Recent studies highlight its potential as a protective factor against environmental toxins and as a therapeutic target for liver disease prevention.
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AKR7A2 Antibody is a Rabbit Polyclonal antibody against AKR7A2. The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011].
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