AK5 antibody
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935106861
info@markelab.com
name
AK5 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00248
tested applications
ELISA, WB
Description
Nucleoside monophosphate(NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adenylate kinase 5 (AK5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:1000-1:10000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 63 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y6K8 |
| Gene ID | 26289 |
| Alias | AK6 |
| Background | Antibody anti-AK5 |
| Status | RUO |
| Note | Mol. Weight 63 kDa |
Descripción
AK5 is a cytosolic adenylate kinase predominantly expressed in the brain, where it plays a role in neural energy metabolism and synaptic function. Unlike other AK isoforms, AK5 demonstrates substrate specificity for ATP/GTP and AMP. It is thought to regulate energy transfer and storage in neurons, particularly in response to neurotransmission demands. AK5 expression correlates with cognitive functions, and its dysfunction has been implicated in neurodevelopmental disorders and memory deficits. AK5 has been shown to influence energy-sensing pathways, such as AMPK, thereby contributing to neuronal survival during energy depletion.
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