AHSG antibody
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name
AHSG antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09916
tested applications
ELISA, WB, IF
Description
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | alpha-2-HS-glycoprotein (AHSG) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500 - 1:2000; IF: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 68 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P02765 |
| Gene ID | 197 |
| Alias | AHSG A2HS,alpha-2-HS-glycoprotein,Fetuin A |
| Background | Antibody anti-AHSG |
| Status | RUO |
| Note | Mol. Weight 68 kDa |
Descripción
Fetuin-A, also known as alpha-2-HS-glycoprotein (AHSG), is a circulating glycoprotein primarily synthesized by the liver. It plays diverse roles in the body, including regulation of mineral metabolism, inhibition of pathological calcification, modulation of insulin signaling, and regulation of inflammation. Fetuin-A functions as an inhibitor of ectopic mineralization by forming soluble complexes with calcium and phosphate ions, preventing their precipitation in soft tissues. Additionally, fetuin-A interacts with various receptors and signaling pathways, influencing insulin sensitivity and glucose homeostasis. Dysregulation of fetuin-A levels has been implicated in metabolic disorders such as diabetes, cardiovascular disease, and chronic kidney disease. Understanding the molecular mechanisms underlying fetuin-A function provides insights into its roles in health and disease, offering potential therapeutic targets for metabolic and cardiovascular conditions. Ongoing research continues to elucidate the multifaceted functions of fetuin-A and its implications for human health
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Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.
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