AGBL3 antibody
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935106861
info@markelab.com
name
AGBL3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00207
tested applications
ELISA, WB, IHC
Description
Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. Isoform 2: Metallocarboxypeptidase that mediates tubulin deglutamylation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP/GTP binding protein-like 3 (AGBL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 73 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NEM8 |
| Gene ID | 340351 |
| Alias | CCP3 |
| Background | Antibody anti-AGBL3 |
| Status | RUO |
| Note | Mol. Weight 73 kDa |
Descripción
AGBL3 is a less-characterized member of the AGBL family but is thought to perform similar functions in tubulin deglutamylation, influencing microtubule behavior and cytoskeletal dynamics. It is expressed in a range of tissues, with potential roles in neuronal development, axon guidance, and intracellular trafficking. Mutations or altered expression of AGBL3 have been associated with neurological disorders and certain cancers, suggesting its involvement in maintaining cellular and tissue homeostasis. Further research is needed to elucidate its specific roles in health and disease.
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