ADAM2 antibody
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935106861
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name
ADAM2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00141
tested applications
ELISA, WB
Description
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ADAM metallopeptidase domain 2 (ADAM2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 100 kDa, 65-75 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q99965 |
| Gene ID | 2515 |
| Alias | fertilin β, fertilin beta,PH30,CT15 ,CRYN1,CRYN2,ADA,-2 |
| Background | Antibody anti-ADAM2 |
| Status | RUO |
| Note | Mol. Weight 100 kDa, 65-75 kDa |
Descripción
ADAM2, also known as ADAM metallopeptidase domain 2, belongs to the ADAM (a disintegrin and metalloproteinase) family of proteins, which are involved in various biological processes such as cell adhesion, fusion, migration, and proteolysis. ADAM2 is specifically implicated in sperm-egg binding. Research on ADAM2 and related proteins has provided valuable insights into the intricate mechanisms governing fertilization. Understanding the role of ADAM2 in sperm-egg interaction has led to the development of potential diagnostic tools for assessing male fertility and identifying causes of infertility. Furthermore, ADAM2 and other members of the ADAM family are being investigated as potential targets for contraceptive development. By targeting proteins involved in sperm-egg binding and fusion, researchers aim to develop contraceptives that specifically inhibit fertilization while minimizing side effects.ADAM2 has also been implicated in other biological processes, including cell adhesion and signaling. Dysregulation of ADAM2 expression or function may contribute to various diseases and conditions beyond infertility, although further research is needed to fully elucidate its broader physiological significance.
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