anti- ACOX2 antibody
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935106861
info@markelab.com
name
anti- ACOX2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00096
tested applications
ELISA, IHC, IF
Description
Oxidizes the CoA esters of the bile acid intermediates di-and tri-hydroxycholestanoic acids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acyl-Coenzyme A oxidase 2, branched chain |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | IF: 1:10-1:100; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 77 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q99424 |
| Gene ID | 8309 |
| Alias | BCOX,BRCOX,CBAS6,THCCox,BRCACOX |
| Background | Antibody anti-ACOX2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Acyl-CoA oxidases (ACOXs) are crucial enzymes involved in the first step of peroxisomal β-oxidation, a pathway responsible for the breakdown of very-long-chain fatty acids (VLCFAs), branched-chain fatty acids, and bile acid intermediates. ACOXs catalyze the oxidation of acyl-CoA to trans-2-enoyl-CoA, producing hydrogen peroxide in the process. ACOX catalyzes the first step of the beta-oxidation pathway within peroxisomes. It oxidizes long-chain acyl-CoA molecules, removing two carbons from the fatty acid chain to produce trans-2-enoyl-CoA. This reaction involves the transfer of electrons to molecular oxygen, leading to the formation of hydrogen peroxide (H2O2). Fatty acid beta-oxidation is a crucial pathway for the catabolism of fatty acids, which are important sources of energy for cells. By breaking down fatty acids into acetyl-CoA units, beta-oxidation provides substrates for energy production through processes such as the citric acid cycle and oxidative phosphorylation. ACOX2 oxidizes branched-chain fatty acids and bile acid intermediates.
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