anti- Aβ42 antibody

Product specifications

Primary Antibodies

Amyloid-beta protein 42

Rabbit

human,mouse,rat

WB: 1:500-1:2000; IHC: 1:20-1:200

polyclonal

Unconjugated

IgG

≥95% as determined by SDS-PAGE

Immunogen affinity purified

100µg

liquid

ELISA, WB, IHC

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

P05067

Aβ42|Amyloid Beta 42|Aβ|1-42|Aβ1-42

Antibody anti-Abeta42

RUO

This product is for research use only.

Abeta42 is a 42-amino acid peptide that differs from Aβ40 by two additional residues at the C-terminal end, resulting in increased hydrophobicity and a greater propensity to aggregate into oligomers and fibrils. Aβ42 is a major component of the amyloid plaques found in Alzheimer’s disease, playing a critical role in its pathogenesis. Its aggregation disrupts neuronal membranes, induces oxidative stress, and triggers inflammatory responses, leading to synaptic dysfunction and neuronal death. Aβ42 is considered more neurotoxic than Aβ40 due to its higher aggregation potential and its ability to form soluble oligomers that impair synaptic signaling. The ratio of Aβ42 to Aβ40 in cerebrospinal fluid is a key biomarker for diagnosing and monitoring Alzheimer’s disease progression. Research is ongoing to understand the mechanisms of Aβ42 aggregation and its interactions with tau proteins, with the goal of developing therapeutic strategies targeting Aβ42 to mitigate Alzheimer’s-related neurodegeneration.

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