Annexin A1 (ANXA1) Antibody (FITC)

Product specifications

Primary Antibodies

Annexin A1 (ANXA1)

Rabbit

Human

WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

FITC

IgG

Purified by antigen-specific affinity chromatography.

200 µl

1 ml

Liquid

WB, IHC, IF/ICC

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Shipped within 5-15 working days.

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.

No

Annexin I,Annexin-1,Calpactin II,Calpactin-2,Chromobindin-9

Antibody anti-ANXA1

RUO

Descripción

ANXA1 is a calcium-dependent phospholipid-binding protein that plays a critical role in anti-inflammatory responses and cell signaling. It regulates the resolution of inflammation by inhibiting the release of pro-inflammatory mediators and modulating the activity of phospholipase A2 (PLA2). ANXA1 also influences cellular processes such as apoptosis, phagocytosis, and membrane repair. It is expressed in various tissues, including immune cells like neutrophils and macrophages, where it supports immune suppression and tissue repair. Dysregulation of ANXA1 has been implicated in cancer progression, where it can act as either a tumor suppressor or promoter depending on the context. Its anti-inflammatory and apoptotic regulatory properties highlight its therapeutic potential in inflammatory diseases, autoimmune disorders, and cancer.

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This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti- inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors.

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