Annexin A1 (ANXA1) Antibody
292.5€ (80 µl)
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Name
Annexin A1 (ANXA1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx034895
Tested Applications
ELISA, WB, IHC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Annexin A1 (ANXA1) Immunogen: Purified His-tagged Human ANXA1 protein |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/100 - 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | Calculated MW: 38.7 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04083 |
| NCBI Accession | NP_000691.1 |
| Alias | Annexin I,Annexin-1,Calpactin II,Calpactin-2,Chromobindin-9 |
| Background | Antibody anti-ANXA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ANXA1 is a calcium-dependent phospholipid-binding protein that plays a critical role in anti-inflammatory responses and cell signaling. It regulates the resolution of inflammation by inhibiting the release of pro-inflammatory mediators and modulating the activity of phospholipase A2 (PLA2). ANXA1 also influences cellular processes such as apoptosis, phagocytosis, and membrane repair. It is expressed in various tissues, including immune cells like neutrophils and macrophages, where it supports immune suppression and tissue repair. Dysregulation of ANXA1 has been implicated in cancer progression, where it can act as either a tumor suppressor or promoter depending on the context. Its anti-inflammatory and apoptotic regulatory properties highlight its therapeutic potential in inflammatory diseases, autoimmune disorders, and cancer.
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