Annexin A1 (ANXA1) Antibody
292.5€ (80 µl)
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name
Annexin A1 (ANXA1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032882
tested applications
ELISA, WB, IHC, FCM
Description
Annexin I belongs to a family of Ca (2+) dependent phospholipid binding proteins which have a molecular weight of approximately 35, 000 to 40, 000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Annexin A1 (ANXA1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04083 |
| Alias | Annexin I,Annexin-1,Calpactin II,Calpactin-2,Chromobindin-9 |
| Background | Antibody anti-ANXA1 |
| Status | RUO |
Descripción
ANXA1 is a calcium-dependent phospholipid-binding protein that plays a critical role in anti-inflammatory responses and cell signaling. It regulates the resolution of inflammation by inhibiting the release of pro-inflammatory mediators and modulating the activity of phospholipase A2 (PLA2). ANXA1 also influences cellular processes such as apoptosis, phagocytosis, and membrane repair. It is expressed in various tissues, including immune cells like neutrophils and macrophages, where it supports immune suppression and tissue repair. Dysregulation of ANXA1 has been implicated in cancer progression, where it can act as either a tumor suppressor or promoter depending on the context. Its anti-inflammatory and apoptotic regulatory properties highlight its therapeutic potential in inflammatory diseases, autoimmune disorders, and cancer.
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