Angiotensin II Receptor, AT2, Amino Terminal Fragment Peptide
221€ (1 mg)
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935106861
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name
Angiotensin II Receptor, AT2, Amino Terminal Fragment Peptide
category
Proteins and Peptides
provider
Abbexa
reference
abx266736
Description
Angiotensin II Receptor, AT2, Amino Terminal Fragment is a peptide.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Angiotensin II Receptor, AT2, Amino Terminal Fragment |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 1877.08 Da |
| Purity | > 95% (HPLC) |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Size 3 | 10 mg |
| Form | Lyophilized |
| Buffer | Not applicable. |
| Availability | Shipped within 10-20 working days. |
| Storage | Store dry at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AGTR2,AT2, ATGR2, MRX88,angiotensin receptor 2,angiotensin II type 2 receptor,AT2 receptor,Agtr2 |
| Background | Protein AGTR2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AGTR2 is a G-protein-coupled receptor (GPCR) that binds angiotensin II, exerting effects that often counterbalance the actions of the angiotensin II receptor type 1 (AGTR1). AGTR2 is expressed in various tissues, including the fetal nervous system, vascular endothelium, kidneys, and heart, and its expression decreases after birth but remains significant in specific contexts, such as injury or disease. Unlike AGTR1, AGTR2 primarily mediates vasodilation, anti-inflammatory effects, antiproliferative actions, and pro-apoptotic signaling, contributing to cardiovascular and tissue protection. AGTR2 signaling involves activation of protein phosphatases, nitric oxide (NO) production, and the modulation of signaling pathways like p38 MAPK and Akt, promoting its protective effects on the vasculature and reducing oxidative stress. Dysregulation of AGTR2 has been linked to vascular remodeling, hypertension, and neurological disorders, including cerebral ischemia and neurodegeneration. Additionally, AGTR2 is implicated in promoting angiogenesis and maintaining neuronal growth during development.
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