Angiotensin II Receptor 2 (AGTR2) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Angiotensin II Receptor 2 (AGTR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx241349
tested applications
ELISA, IHC
Description
AGTR2 Antibody is a Rabbit Polyclonal against AGTR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiotensin II Receptor 2 (AGTR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P50052 |
| Gene ID | 186 |
| Alias | AGTR2,AT2, ATGR2, MRX88,angiotensin receptor 2,angiotensin II type 2 receptor,AT2 receptor,Agtr2 |
| Background | Antibody anti-AGTR2 |
| Status | RUO |
Descripción
AGTR2 is a G-protein-coupled receptor (GPCR) that binds angiotensin II, exerting effects that often counterbalance the actions of the angiotensin II receptor type 1 (AGTR1). AGTR2 is expressed in various tissues, including the fetal nervous system, vascular endothelium, kidneys, and heart, and its expression decreases after birth but remains significant in specific contexts, such as injury or disease. Unlike AGTR1, AGTR2 primarily mediates vasodilation, anti-inflammatory effects, antiproliferative actions, and pro-apoptotic signaling, contributing to cardiovascular and tissue protection. AGTR2 signaling involves activation of protein phosphatases, nitric oxide (NO) production, and the modulation of signaling pathways like p38 MAPK and Akt, promoting its protective effects on the vasculature and reducing oxidative stress. Dysregulation of AGTR2 has been linked to vascular remodeling, hypertension, and neurological disorders, including cerebral ischemia and neurodegeneration. Additionally, AGTR2 is implicated in promoting angiogenesis and maintaining neuronal growth during development.
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