Angiotensin Converting Enzyme 2 (ACE2) Protein
6136€ (1 mg)
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name
Angiotensin Converting Enzyme 2 (ACE2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx160081
tested applications
ELISA, WB
Description
Human Angiotensin Converting Enzyme 2 (ACE2) Protein is a recombinant protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Angiotensin Converting Enzyme 2 (ACE2) |
| Host | HEK293 cells |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Observed MW | Concentration: 1.44 mg/ml Tag: C-Terminal Fc1 tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Size 1 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.2-7.4. Buffer contains no preservative. |
| Availability | Shipped within 10-20 working days. |
| Storage | Store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | Yes |
| Alias | ACEH,Peptidyl-Dipeptidase A |
| Background | Protein ACE2 |
| Status | RUO |
| Note | This product is for research use only. This product is shipped with dry ice. |
Descripción
Angiotensin I Converting Enzyme 2 (ACE2) is a transmembrane protein that serves as a key regulator of the renin-angiotensin system (RAS) by catalyzing the conversion of angiotensin II (a potent vasoconstrictor) into angiotensin 1-7, which has vasodilatory, anti-inflammatory, and anti-fibrotic effects. ACE2 is highly expressed in the lungs, heart, kidneys, and gastrointestinal tract, and it plays a crucial role in maintaining cardiovascular and pulmonary homeostasis. Beyond its enzymatic function, ACE2 gained significant attention as the cellular entry receptor for the SARS-CoV and SARS-CoV-2 viruses, where it facilitates viral binding and internalization via interactions with the viral spike (S) protein. Dysregulation of ACE2 expression has been implicated in conditions such as hypertension, heart failure, acute lung injury, and COVID-19-related complications. Therapeutic strategies targeting ACE2, such as recombinant soluble ACE2 and RAS modulators, are being explored to counteract these pathologies. ACE2's dual role in regulating vascular function and serving as a viral receptor highlights its significance in both physiology and disease.
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