Angiotensin-Converting Enzyme 2 (ACE2) Antibody
559€ (100 µl)
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935106861
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name
Angiotensin-Converting Enzyme 2 (ACE2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034955
tested applications
ELISA, WB
Description
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. This antibody is supplied as crude ascites.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiotensin-Converting Enzyme 2 (ACE2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgM |
| Purification | Unpurified crude ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BYF1 |
| NCBI Accession | NP_068576.1 |
| Alias | ACEH,Peptidyl-Dipeptidase A |
| Background | Antibody anti-ACE2 |
| Status | RUO |
Descripción
Angiotensin I Converting Enzyme 2 (ACE2) is a transmembrane protein that serves as a key regulator of the renin-angiotensin system (RAS) by catalyzing the conversion of angiotensin II (a potent vasoconstrictor) into angiotensin 1-7, which has vasodilatory, anti-inflammatory, and anti-fibrotic effects. ACE2 is highly expressed in the lungs, heart, kidneys, and gastrointestinal tract, and it plays a crucial role in maintaining cardiovascular and pulmonary homeostasis. Beyond its enzymatic function, ACE2 gained significant attention as the cellular entry receptor for the SARS-CoV and SARS-CoV-2 viruses, where it facilitates viral binding and internalization via interactions with the viral spike (S) protein. Dysregulation of ACE2 expression has been implicated in conditions such as hypertension, heart failure, acute lung injury, and COVID-19-related complications. Therapeutic strategies targeting ACE2, such as recombinant soluble ACE2 and RAS modulators, are being explored to counteract these pathologies. ACE2's dual role in regulating vascular function and serving as a viral receptor highlights its significance in both physiology and disease.
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ACE2 antibody
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.
Ver Producto