Angiotensin Converting Enzyme 2 (ACE2) Antibody
253.5€ (50 µg)
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Name
Angiotensin Converting Enzyme 2 (ACE2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx376502
Tested Applications
WB, IHC
Description
Angiotensin Converting Enzyme 2 (ACE2) Antibody is a Mouse Monoclonal antibody for the detection of Human ACE2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Angiotensin Converting Enzyme 2 (ACE2) Immunogen: Recombinant Human ACE2 protein |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 0.62 mg/ml |
| Recommended Dilution | WB: 1/1000 - 1/4000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | C817 |
| Purification | Purified from Mouse ascites by Protein G chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BYF1 |
| Gene ID | 59272 |
| NCBI Accession | NP_001358344.1 |
| Alias | ACEH,Peptidyl-Dipeptidase A |
| Background | Antibody anti-ACE2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Angiotensin I Converting Enzyme 2 (ACE2) is a transmembrane protein that serves as a key regulator of the renin-angiotensin system (RAS) by catalyzing the conversion of angiotensin II (a potent vasoconstrictor) into angiotensin 1-7, which has vasodilatory, anti-inflammatory, and anti-fibrotic effects. ACE2 is highly expressed in the lungs, heart, kidneys, and gastrointestinal tract, and it plays a crucial role in maintaining cardiovascular and pulmonary homeostasis. Beyond its enzymatic function, ACE2 gained significant attention as the cellular entry receptor for the SARS-CoV and SARS-CoV-2 viruses, where it facilitates viral binding and internalization via interactions with the viral spike (S) protein. Dysregulation of ACE2 expression has been implicated in conditions such as hypertension, heart failure, acute lung injury, and COVID-19-related complications. Therapeutic strategies targeting ACE2, such as recombinant soluble ACE2 and RAS modulators, are being explored to counteract these pathologies. ACE2's dual role in regulating vascular function and serving as a viral receptor highlights its significance in both physiology and disease.
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