Angiopoietin-Related Protein 3 (ANGPTL3) Antibody Pair

975€ (5 × 96 tests)
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935106861
info@markelab.com
name
Angiopoietin-Related Protein 3 (ANGPTL3) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370536
tested applications
ELISA
Description
Angiopoietin-Related Protein 3 (ANGPTL3) Antibody Pair for use in Sandwich ELISA assay development.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Antibody Pairs |
Immunogen Target | Angiopoietin-Related Protein 3 (ANGPTL3) |
Reactivity | Mouse |
Assay Data | Detection Antibody Biotinilated |
Assay Type | Sandwich |
Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
Size 1 | 5 × 96 tests |
Size 2 | 10 × 96 tests |
Form | Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
Tested Applications | ELISA |
Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
Availability | Please enquire. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | ANG-5,ANGPT5,ANL3,FHBL2 |
Background | Antibody Pair for ANGPTL3 |
Status | RUO |
Note | This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only. |
Descripción
ANGPTL3 is a secreted glycoprotein primarily expressed in the liver, where it plays a central role in regulating lipid metabolism. ANGPTL3 functions as an inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), leading to increased plasma levels of triglycerides, cholesterol, and low-density lipoproteins (LDL). It is a key regulator of systemic energy homeostasis, influencing lipid storage and transport under fasting and fed conditions. Genetic loss-of-function mutations in ANGPTL3 are associated with familial combined hypolipidemia, a condition characterized by significantly reduced levels of triglycerides, LDL, and HDL cholesterol, highlighting its critical role in lipid metabolism. ANGPTL3 is also implicated in cardiovascular diseases, where elevated levels are linked to atherosclerosis and coronary artery disease due to lipid accumulation and vascular inflammation. In cancer, ANGPTL3 promotes tumor angiogenesis and metastasis by regulating endothelial cell proliferation and migration. Its role as a regulator of lipid metabolism and vascular biology makes ANGPTL3 a promising therapeutic target for treating hyperlipidemia, atherosclerosis, and related metabolic disorders.
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