Angiopoietin-Related Protein 3 (ANGPTL3) Antibody
234€ (5 µg)
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935106861
info@markelab.com
name
Angiopoietin-Related Protein 3 (ANGPTL3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx137550
Description
Angiopoietin-Related Protein 3 (ANGPTL3) Antibody is a Mouse Monoclonal antibody against Angiopoietin-Related Protein 3 (ANGPTL3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiopoietin-Related Protein 3 (ANGPTL3) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | ANG-5,ANGPT5,ANL3,FHBL2 |
| Background | Antibody anti-ANGPTL3 |
| Status | RUO |
Descripción
ANGPTL3 is a secreted glycoprotein primarily expressed in the liver, where it plays a central role in regulating lipid metabolism. ANGPTL3 functions as an inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), leading to increased plasma levels of triglycerides, cholesterol, and low-density lipoproteins (LDL). It is a key regulator of systemic energy homeostasis, influencing lipid storage and transport under fasting and fed conditions. Genetic loss-of-function mutations in ANGPTL3 are associated with familial combined hypolipidemia, a condition characterized by significantly reduced levels of triglycerides, LDL, and HDL cholesterol, highlighting its critical role in lipid metabolism. ANGPTL3 is also implicated in cardiovascular diseases, where elevated levels are linked to atherosclerosis and coronary artery disease due to lipid accumulation and vascular inflammation. In cancer, ANGPTL3 promotes tumor angiogenesis and metastasis by regulating endothelial cell proliferation and migration. Its role as a regulator of lipid metabolism and vascular biology makes ANGPTL3 a promising therapeutic target for treating hyperlipidemia, atherosclerosis, and related metabolic disorders.
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