Angiopoietin 2 (ANGPT2) Antibody (Biotin)

Este producto es parte de ANGPT - Angiopoietin
Angiopoietin 2 (ANGPT2) Antibody (Biotin)

Pida mas información

935106861

info@markelab.com

Precio

162.5€ (20 µg)

Antibody anti-ANGPT2

proveedor

Abbexa

reference

abx105138

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Polyclonal

Descripción

Angiopoietin 2 Antibody (Biotin) is a Rabbit Polyclonal antibody against Angiopoietin 2 conjugated to Biotin. Angiopoietin 2 binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. It can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2 mediated loosening of cell matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.


Background

ANGPT2 is a secreted protein that functions as a context-dependent antagonist or agonist of the Tie2 receptor, depending on cellular and environmental conditions. ANGPT2 disrupts ANGPT1-Tie2 signaling under inflammatory or angiogenic conditions, leading to increased vascular permeability, endothelial activation, and vessel destabilization. ANGPT2 is expressed primarily in the vasculature, where it facilitates vascular remodeling during angiogenesis, inflammation, and tissue repair. It plays a key role in pathological angiogenesis observed in cancer, where it promotes the formation of abnormal, leaky blood vessels that support tumor growth and metastasis. ANGPT2 also acts as a regulator of inflammatory responses by enhancing endothelial activation and leukocyte recruitment. Elevated ANGPT2 levels are associated with diseases such as sepsis, diabetic vascular complications, and cardiovascular diseases, where excessive vascular permeability and endothelial dysfunction occur. ANGPT2 serves as a biomarker for vascular injury and a potential therapeutic target for stabilizing blood vessels in pathological conditions.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Mouse


immunogen target

Angiopoietin 2 (ANGPT2)


host

Rabbit


conjugation

Biotin


form

Liquid


tested applications

ELISA


purity

> 95%


purification

Purified by Protein G.


buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.


size 1

20 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


storage

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.


or code

ANGPT2


dry ice

No


availability

Shipped within 5-10 working days.


alias

AGPT2,ANG2,LMPHM10


note

This product is for research use only.


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