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Angiopoietin 2 (ANGPT2) Antibody (Biotin)
proveedor
Abbexareference
abx105138Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
PolyclonalDescripción
Angiopoietin 2 Antibody (Biotin) is a Rabbit Polyclonal antibody against Angiopoietin 2 conjugated to Biotin. Angiopoietin 2 binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. It can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2 mediated loosening of cell matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Background
Angiogenin 2 (ANG2), also known as Angiopoietin 2 (ANGPT2), plays a role in facilitating ribonuclease activity and is involved in various cellular processes, including cardiac muscle cell development, responses to glucose stimulus, and the positive regulation of protein phosphorylation. It exhibits a strong binding affinity to placental ribonuclease inhibitor but possesses very low ribonuclease activity itself. ANG2 is notably potent in promoting angiogenesis, contributing to the vascularization of both normal and malignant tissues. One of its significant functions is the inhibition of protein synthesis through the specific hydrolysis of cellular transfer RNAs (tRNAs). It is recognized by several aliases, including ANG2, Angiopoietin 2, ANG-2, ANGPT2, and AGPT2.
Background
La Angiogenina 2 (ANG2), también conocida como angiopoyetina 2 (ANGPT2), desempeña un papel en la facilitación de la actividad de la ribonucleasa y participa en diversos procesos celulares, incluido el desarrollo de las células del músculo cardíaco, las respuestas al estímulo de la glucosa y la regulación positiva de la fosforilación de proteínas. Muestra una fuerte afinidad de unión al inhibidor de la ribonucleasa placentaria, pero posee una actividad de ribonucleasa muy baja. ANG2 es notablemente potente para promover la angiogénesis, contribuyendo a la vascularización de tejidos tanto normales como malignos. Una de sus funciones importantes es la inhibición de la síntesis de proteínas mediante la hidrólisis específica de los ARN de transferencia celular (ARNt). Se reconoce por varios alias, incluidos ANG2, Angiopoyetin 2, ANG-2, ANGPT2 y AGPT2.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Mouse
immunogen target
Angiopoietin 2 (ANGPT2)
host
Rabbit
conjugation
Biotin
form
Liquid
tested applications
ELISA
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
or code
ANGPT2
dry ice
No
availability
Shipped within 5-10 working days.
alias
AGPT2,ANG2,LMPHM10
uniprot id
note
This product is for research use only.
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