Angiopoietin 2 (ANGPT2) Antibody
364€ (100 µg)
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935106861
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name
Angiopoietin 2 (ANGPT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230392
tested applications
ELISA, WB, IHC, IF/ICC
Description
Angiopoietin 2 Antibody is a Rabbit Polyclonal against Angiopoietin 2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Angiopoietin 2 (ANGPT2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/20 - 1/200, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15123 |
| Gene ID | 285 |
| OMIM | 601922 |
| Alias | AGPT2,ANG2,LMPHM10 |
| Background | Antibody anti-ANGPT2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ANGPT2 is a secreted protein that functions as a context-dependent antagonist or agonist of the Tie2 receptor, depending on cellular and environmental conditions. ANGPT2 disrupts ANGPT1-Tie2 signaling under inflammatory or angiogenic conditions, leading to increased vascular permeability, endothelial activation, and vessel destabilization. ANGPT2 is expressed primarily in the vasculature, where it facilitates vascular remodeling during angiogenesis, inflammation, and tissue repair. It plays a key role in pathological angiogenesis observed in cancer, where it promotes the formation of abnormal, leaky blood vessels that support tumor growth and metastasis. ANGPT2 also acts as a regulator of inflammatory responses by enhancing endothelial activation and leukocyte recruitment. Elevated ANGPT2 levels are associated with diseases such as sepsis, diabetic vascular complications, and cardiovascular diseases, where excessive vascular permeability and endothelial dysfunction occur. ANGPT2 serves as a biomarker for vascular injury and a potential therapeutic target for stabilizing blood vessels in pathological conditions.
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