Angiopoietin-1 Receptor / TIE2 (TEK) Antibody

Este producto es parte de TEK - TEK receptor tyrosine kinase
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637€ (100 µl)

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935106861
info@markelab.com
name
Angiopoietin-1 Receptor / TIE2 (TEK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx116024
tested applications
ELISA, WB

Description

TIE2 Antibody is a Rabbit Polyclonal antibody against TIE2.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Angiopoietin-1 Receptor / TIE2 (TEK)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q02763
Gene ID
7010
NCBI Accession
NP_000450.2
OMIM
600195
Alias
Angiopoietin-1 receptor,Endothelial tyrosine kinase,TIE2,VMCM,GLC3E,TIE-2,VMCM1,CD202B,Tyrosine-protein kinase receptor TEK,Tunica interna endothelial cell kinase
Background
Antibody anti-TEK
Status
RUO

Descripción

TEK, also known as TEK receptor tyrosine kinase (also termed Tie2 in some literature), is a receptor tyrosine kinase (RTK) with significant roles in vascular development, maintenance, and angiogenesis. Receptor tyrosine kinases are a class of cell surface receptors that, upon ligand binding, activate intracellular signaling cascades through phosphorylation. Specifically, the TEK/Tie2 receptor is primarily expressed in endothelial cells, which line blood vessels, as well as in certain subsets of hematopoietic cells. Its ligand, angiopoietin, specifically angiopoietins-1 and -2 (ANGPT1 and ANGPT2), modulates TEK signaling and plays essential roles in vessel stabilization, endothelial survival, and inflammatory responses. TEK signaling plays an essential role in regulating vascular quiescence and homeostasis. In developing and mature vasculature, TEK helps balance angiogenesis, where new blood vessels form from existing ones, with vascular stability and permeability. This function makes TEK a crucial player in several physiological and pathological processes, from wound healing to cancer and other angiogenesis-dependent diseases. Dysfunctional TEK signaling has been implicated in a range of vascular and inflammatory diseases, including tumor angiogenesis, diabetic retinopathy, and sepsis.

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