Anaphase Promoting Complex Subunit 2 (ANAPC2) Antibody
357.5€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Anaphase Promoting Complex Subunit 2 (ANAPC2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036747
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ANAPC2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase Promoting Complex Subunit 2 (ANAPC2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ANAPC2,APC2,Cyclosome subunit 2 |
| Background | Antibody anti-ANAPC2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ANAPC2 is a core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) and functions as part of the catalytic module that regulates its E3 ubiquitin ligase activity. ANAPC2 interacts directly with ANAPC11, the RING finger protein, and facilitates the recruitment of E2 ubiquitin-conjugating enzymes to catalyze the transfer of ubiquitin onto substrates such as cyclin B, securin, and other key cell cycle regulators. This activity ensures the timely degradation of APC/C targets, driving the metaphase-to-anaphase transition and promoting exit from mitosis. ANAPC2 is critical for maintaining chromosomal stability and proper cell cycle progression. Dysregulation of ANAPC2 impairs APC/C activity, leading to mitotic defects, aneuploidy, and genomic instability, which are associated with cancer development and progression. Its catalytic role highlights ANAPC2 as a key player in cell division and a potential therapeutic target for controlling aberrant cell proliferation in cancers.
Related Products
ANAPC2 antibody
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
Ver Producto
Recombinant Human ANAPC2
Ver Producto
Anaphase Promoting Complex Subunit 2 (ANAPC2) Antibody
ANAPC2 Antibody is a Rabbit Polyclonal Antibody against ANAPC2.
Ver Producto