Anaphase-Promoting Complex Subunit 10 (ANAPC10) Antibody
383.5€ (100 µl)
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935106861
info@markelab.com
name
Anaphase-Promoting Complex Subunit 10 (ANAPC10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx224354
tested applications
ELISA, WB, IF/ICC, FCM
Description
ANAPC10 Antibody is a Mouse Monoclonal against ANAPC10.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase-Promoting Complex Subunit 10 (ANAPC10) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75874 |
| Gene ID | 3417 |
| OMIM | 137800 |
| Alias | ANAPC10,APC10 |
| Background | Antibody anti-ANAPC10 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ANAPC10 is a critical subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) and functions as a key adaptor in the ubiquitin ligase activity of the complex. ANAPC10 interacts with other core subunits, including CDC20 and CDH1, to facilitate the recruitment of substrates for ubiquitination. It helps target key cell cycle proteins such as cyclin B, securin, and geminin for proteasomal degradation, thereby driving progression through mitosis and maintaining proper cell cycle regulation. ANAPC10 also ensures the fidelity of chromosome segregation by preventing premature separation of sister chromatids. Dysregulation of ANAPC10 impairs APC/C activity, leading to chromosomal instability, mitotic arrest, and increased risk of cancer. It has been implicated in tumorigenesis due to its role in cell cycle checkpoint control and regulation of proliferation. Its function as an essential adaptor makes ANAPC10 a promising target for therapeutic strategies aimed at modulating mitotic progression in cancer cells.
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