Amyloid Beta Precursor Protein Binding Family A Member 2 (APBA2) Antibody

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935106861
info@markelab.com
Precio
250€ (50 µl)
Antibody anti-APBA2
proveedor
Abbexareference
abx210431Tested Applications
ELISA, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
APBA2 Antibody is a Rabbit Polyclonal against APBA2.
Background
APBA2 is a member of the X11 protein family, known for its role in interacting with the amyloid-beta precursor protein (APP). APBA2 is predominantly expressed in neuronal tissues, where it contributes to the regulation of APP trafficking, processing, and stabilization. This protein is involved in modulating amyloid-beta peptide production, a critical factor in Alzheimer’s disease pathology. By binding APP through its phosphotyrosine-binding (PTB) domain, APBA2 helps reduce the formation of amyloid-beta aggregates, which are the hallmark of neurodegeneration. Apart from its role in APP metabolism, APBA2 has been shown to participate in intracellular trafficking, synaptic vesicle function, and neuronal signal transduction pathways. Dysfunction of APBA2 may lead to abnormal APP processing, contributing to increased amyloid-beta deposition, oxidative stress, and neurotoxicity. Studies indicate that APBA2 is crucial for maintaining synaptic plasticity and cognitive functions, and its dysregulation may play a role in Alzheimer’s disease and other neurodegenerative disorders. As a molecular chaperone and stabilizer of APP, APBA2 is being explored as a potential therapeutic target to reduce amyloid plaque burden and preserve neuronal function in neurodegenerative diseases.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Amyloid Beta Precursor Protein Binding Family A Member 2 (APBA2)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, IHC
purification
Antigen Affinity Chromatography.
buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
size 1
50 µl
size 2
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
APBA2
dry ice
No
availability
Shipped within 5-10 working days.
alias
APBA2, D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L, amyloid beta precursor protein binding family A member 2
uniprot id
note
This product is for research use only.
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