Amyloid-beta Precursor Protein (APP) Antibody
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935106861
info@markelab.com
Precio
169€ (20 µg)
Antibody anti-APP
proveedor
Abbexareference
abx109256Tested Applications
ELISA, WB, IHC, IF/ICCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
Amyloid beta A4 protein Antibody is a Rabbit Polyclonal antibody against Amyloid beta A4 protein.
Background
APP is a transmembrane glycoprotein widely expressed in the brain and peripheral tissues that plays a critical role in neuronal development, synaptic plasticity, and cell adhesion APP is proteolytically processed by enzymes such as α-secretase, β-secretase, and γ-secretase, leading to the production of various fragments, including the beta-amyloid (Aβ) peptide Abnormal processing of APP and the accumulation of Aβ peptides form amyloid plaques, which are a hallmark of Alzheimer’s disease and contribute to neurotoxicity and neurodegeneration APP also interacts with various proteins to mediate intracellular signaling and cellular responses Mutations in the APP gene are associated with early-onset familial Alzheimer’s disease, highlighting its role in the pathogenesis of neurodegenerative disorders
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Amyloid-beta Precursor Protein (APP)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC
purity
> 95%
purification
Purified by Protein G.
recommended dilution
WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
APP
dry ice
No
availability
Shipped within 5-10 working days.
alias
AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,PN-II,preA4,CTFgamma,alpha-sAPP,Alzheimer disease amyloid protein
uniprot id
NCBI accession
NP_000475.1, NM_000484.3
note
Concentration: 0.25 mg/ml -
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