Amyloid Beta Precursor Like Protein 1 (APLP1) Antibody

Amyloid Beta Precursor Like Protein 1 (APLP1) Antibody

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935106861

info@markelab.com

Precio

175€ (20 µl)

proveedor

Abbexa

reference

abx002045

Tested Applications

WB, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

APLP1 Antibody is a Rabbit Polyclonal antibody against APLP1. This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Background

Amyloid precursor protein (APP) is a highly conserved protein. Amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are homologous of APP. APLP1 was the first identified homologue , while APLP2, was later recognized as another homologue of APP . These three proteins share significant sequence similarity and possess conserved domain structures. APLP1, a type I transmembrane protein, plays a crucial role in synaptic adhesion and synaptogenesis. Is actively involved in the formation of protein-protein complexes that serve as bridges between closely adjacent cells, facilitating cell-cell interactions and communication

Background

La proteína precursora de amiloide (APP) es una proteína altamente conservada. La proteína 1 similar al precursor de amiloide (APLP1) y la proteína 2 similar al precursor de amiloide (APLP2) son homólogas de APP. APLP1 fue el primer homólogo identificado, mientras que APLP2 fue reconocido más tarde como otro homólogo de APP. Estas tres proteínas comparten una similitud de secuencia significativa y poseen estructuras de dominio conservadas. APLP1, una proteína transmembrana de tipo I, desempeña un papel crucial en la adhesión sináptica y la sinaptogénesis. Participa activamente en la formación de complejos proteína-proteína que sirven como puentes entre células estrechamente adyacentes, facilitando las interacciones y la comunicación entre células.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

Amyloid Beta Precursor Like Protein 1 (APLP1)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IF/ICC


purification

Purified by affinity chromatography.


buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.


size 1

20 µl


size 2

50 µl


size 3

100 µl


size 4

200 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

APLP1


dry ice

No


availability

Shipped within 5-10 working days.


alias

APLP1,Amyloid beta (A4) precursor-like protein 1 By Similarity,Amyloid-like protein 1


NCBI accession

NP_005157.1


note

This product is for research use only.


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