Amyloid-Beta A4 Precursor Protein-Binding Family A Member 2 (APBA2) Antibody

Background

APBA2 is a member of the X11 protein family, known for its role in interacting with the amyloid-beta precursor protein (APP). APBA2 is predominantly expressed in neuronal tissues, where it contributes to the regulation of APP trafficking, processing, and stabilization. This protein is involved in modulating amyloid-beta peptide production, a critical factor in Alzheimer’s disease pathology. By binding APP through its phosphotyrosine-binding (PTB) domain, APBA2 helps reduce the formation of amyloid-beta aggregates, which are the hallmark of neurodegeneration. Apart from its role in APP metabolism, APBA2 has been shown to participate in intracellular trafficking, synaptic vesicle function, and neuronal signal transduction pathways. Dysfunction of APBA2 may lead to abnormal APP processing, contributing to increased amyloid-beta deposition, oxidative stress, and neurotoxicity. Studies indicate that APBA2 is crucial for maintaining synaptic plasticity and cognitive functions, and its dysregulation may play a role in Alzheimer’s disease and other neurodegenerative disorders. As a molecular chaperone and stabilizer of APP, APBA2 is being explored as a potential therapeutic target to reduce amyloid plaque burden and preserve neuronal function in neurodegenerative diseases.