AMP deaminase 3 (AMPD3) Antibody
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935106861
info@markelab.com
Precio
221€ (50 µg)
Antibody anti-AMPD3
proveedor
Abbexareference
abx326562Tested Applications
ELISA, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
AMPD3 Antibody is a Rabbit Polyclonal against AMPD3.
Background
AMPD3 is an isoform of AMP deaminase predominantly expressed in erythrocytes (red blood cells), where it catalyzes the conversion of AMP to IMP to regulate ATP and nucleotide levels under energy stress. AMPD3 activity is essential for maintaining erythrocyte energy homeostasis, as it helps sustain ATP levels and prevents the depletion of adenine nucleotides during cellular stress. Mutations in the AMPD3 gene lead to erythrocyte AMP deaminase deficiency, a condition characterized by reduced IMP production and altered ATP metabolism, although most affected individuals remain asymptomatic. AMPD3 has been implicated in hemolytic anemias and other red blood cell disorders where impaired energy metabolism compromises erythrocyte survival and function. Beyond its role in erythrocyte physiology, AMPD3 contributes to systemic purine metabolism and may influence energy balance in other tissues. Its importance in regulating erythrocyte energy levels highlights its critical role in red blood cell longevity and overall cellular energy balance.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
AMP deaminase 3 (AMPD3)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, IHC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1/40000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
size 1
50 µg
size 2
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AMPD3
dry ice
No
availability
Shipped within 5-10 working days.
alias
AMP deaminase isoform E
uniprot id
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