AMP deaminase 2 (AMPD2) Antibody
221€ (50 µg)
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Name
AMP deaminase 2 (AMPD2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx327983
Tested Applications
ELISA, WB
Description
AMPD2 Antibody is a Rabbit Polyclonal against AMPD2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: AMP deaminase 2 (AMPD2) Immunogen: Synthesized peptide derived from the Internal region of human AMPD2. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01433 |
| Gene ID | 271 |
| Alias | AMP deaminase isoform L |
| Background | Antibody anti-AMPD2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AMPD2 is an isoform of AMP deaminase predominantly expressed in the liver and brain, where it catalyzes the conversion of AMP to IMP as part of the purine nucleotide cycle. AMPD2 plays an essential role in hepatic energy metabolism, facilitating nucleotide turnover and maintaining purine homeostasis during conditions of energy stress. In the liver, AMPD2 activity is tightly linked to gluconeogenesis and urea cycle regulation, as it supplies intermediates such as fumarate for energy generation and ammonia detoxification. Mutations in AMPD2 are associated with pontocerebellar hypoplasia type 9 (PCH9), a severe neurodevelopmental disorder characterized by brain atrophy, microcephaly, and motor impairments due to disrupted purine metabolism. AMPD2 dysfunction leads to impaired nucleotide cycling, energy imbalance, and neuronal loss, highlighting its importance in brain development and function. Its role in liver metabolism and neurological health underscores its potential as a target for metabolic and neurodegenerative disorders.
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