AMP Deaminase 1 (AMPD1) Antibody
312€ (60 µl)
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935106861
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name
AMP Deaminase 1 (AMPD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx123046
tested applications
WB
Description
AMPD1 Antibody is a Rabbit Polyclonal Antibody against AMPD1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AMP Deaminase 1 (AMPD1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23109 |
| Gene ID | 270 |
| Alias | Myoadenylate deaminase |
| Background | Antibody anti-AMPD1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
AMPD1 is a key enzyme in the purine nucleotide cycle that catalyzes the deamination of adenosine monophosphate (AMP) to inosine monophosphate (IMP), releasing ammonia as a byproduct. AMPD1 is primarily expressed in skeletal muscle and plays a critical role in energy metabolism by regulating adenine nucleotide levels during high-energy demands such as intense exercise. This activity helps replenish ATP levels through the recycling of IMP and promotes the balance of cellular energy homeostasis. Mutations in the AMPD1 gene can lead to AMP deaminase deficiency, also known as myoadenylate deaminase deficiency (MADD), a metabolic disorder characterized by muscle weakness, fatigue, and exercise intolerance. AMPD1 deficiency affects ATP production and disrupts normal purine metabolism, although many individuals remain asymptomatic. AMPD1 is also implicated in conditions like metabolic myopathies and has been studied for its role in enhancing exercise recovery and performance. Its regulation of energy metabolism highlights its importance in maintaining muscle function under stress.
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AMPD1-Specific antibody
AMPD1, also named as MAD and MADA, belongs to the adenosine and AMP deaminases family. AMP deaminase plays a critical role in energy metabolism. It catalyzes the reaction: AMP + H2O = IMP + NH3. Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type(AMPDDM) which is a metabolic disorder resulting in exercise-related myopathy. The antibody is specific to AMPD1.
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AMP Deaminase 1 (AMPD1) Antibody
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