AMP Deaminase 1 (AMPD1) Antibody
273€ (200 µl)
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935106861
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name
AMP Deaminase 1 (AMPD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432324
tested applications
P-ELISA
Description
AMPD1 Antibody is a Goat Polyclonal antibody against AMPD1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | AMP Deaminase 1 (AMPD1) |
| Host | Goat |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 270 |
| NCBI Accession | NP_000027.1 |
| Alias | Myoadenylate deaminase |
| Background | Antibody anti-AMPD1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
AMPD1 is a key enzyme in the purine nucleotide cycle that catalyzes the deamination of adenosine monophosphate (AMP) to inosine monophosphate (IMP), releasing ammonia as a byproduct. AMPD1 is primarily expressed in skeletal muscle and plays a critical role in energy metabolism by regulating adenine nucleotide levels during high-energy demands such as intense exercise. This activity helps replenish ATP levels through the recycling of IMP and promotes the balance of cellular energy homeostasis. Mutations in the AMPD1 gene can lead to AMP deaminase deficiency, also known as myoadenylate deaminase deficiency (MADD), a metabolic disorder characterized by muscle weakness, fatigue, and exercise intolerance. AMPD1 deficiency affects ATP production and disrupts normal purine metabolism, although many individuals remain asymptomatic. AMPD1 is also implicated in conditions like metabolic myopathies and has been studied for its role in enhancing exercise recovery and performance. Its regulation of energy metabolism highlights its importance in maintaining muscle function under stress.
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