Aminolevulinate Delta Synthase 1 (ALAS1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
ALAS1 Antibody is a Rabbit Polyclonal against ALAS1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aminolevulinate Delta Synthase 1 (ALAS1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13196 |
| Gene ID | 211 |
| Alias | ALAS1,ALAS3,ALASH,Delta-ALA synthase 1 |
| Background | Antibody anti-ALAS1 |
| Status | RUO |
5-Aminolevulinate Synthase 1 (ALAS1) is the ubiquitously expressed, non-specific isoform of the enzyme catalyzing the first and rate-limiting step of heme biosynthesis. ALAS1 converts glycine and succinyl-CoA into 5-aminolevulinic acid (ALA) within mitochondria, a critical precursor in the heme production pathway. Its expression and activity are tightly regulated by intracellular heme levels, reflecting its central role in maintaining heme homeostasis. ALAS1 is induced in response to increased demand for cytochromes in liver cells, particularly during drug metabolism and detoxification processes mediated by cytochrome P450 enzymes. Dysregulation of ALAS1 can lead to disorders such as acute intermittent porphyria (AIP), characterized by the accumulation of toxic heme precursors, resulting in neurovisceral symptoms. Therapeutic modulation of ALAS1 activity, including heme supplementation or small-molecule inhibitors, is a key strategy in managing porphyric crises and related metabolic dysfunctions.
Related Products
Aminolevulinate Delta Synthase 1 (ALAS1) Antibody
ALAS1 Antibody is a Rabbit Polyclonal antibody against ALAS1. This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Ver Producto
Rat Aminolevulinate delta Synthase 1 (ALAS1) ELISA Kit
Rat Aminolevulinate delta Synthase 1 (ALAS1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Aminolevulinate delta Synthase 1 (ALAS1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Aminolevulinate Delta Synthase 1 (ALAS1)
Ver Producto
Aminolevulinate Delta Synthase 1 (ALAS1) Antibody
ALAS1 Antibody is a Rabbit Polyclonal against ALAS1.
Ver Producto