ALX Homeobox 4 (ALX4) Antibody
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Description
ALX4 Antibody is a Rabbit Polyclonal against ALX4.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ALX Homeobox 4 (ALX4) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H161 |
| Gene ID | 60529 |
| Alias | CRS5,FND2 |
| Background | Antibody anti-ALX4 |
| Status | RUO |
Descripción
ALX4 is a homeobox transcription factor critical for skeletal development, limb formation, and hair follicle regulation. ALX4 is highly expressed in mesenchymal progenitor cells during embryonic development, where it regulates the formation of cranial bones, limbs, and other skeletal structures. Mutations in ALX4 are associated with parietal foramina, a congenital condition characterized by defects in skull ossification, as well as alopecia and hair pattern abnormalities. ALX4 functions by coordinating signaling pathways such as Wnt and BMP, which control mesenchymal differentiation, osteoblast activity, and hair follicle cycling. Loss of ALX4 function can lead to delayed skull closure, limb malformations, and impaired bone mineralization. ALX4 is also implicated in tumor suppression, as its downregulation has been observed in cancers where mesenchymal regulation is disrupted. Its role in skeletal and hair follicle development underscores its importance as a key regulator of mesenchymal differentiation and morphogenesis.
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