ALX Homeobox 1 (ALX1) Antibody (FITC)
169€ (20 µg)
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Name
ALX Homeobox 1 (ALX1) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx317415
Description
ALX1 Antibody (FITC) is a Rabbit Polyclonal against ALX1 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ALX Homeobox 1 (ALX1) Immunogen: Recombinant Human ALX homeobox protein 1 protein (10-304AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15699 |
| Gene ID | 8092 |
| OMIM | 601527 |
| Alias | ALX1,CART1,FND3,HEL23 |
| Background | Antibody anti-ALX1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALX1 is a homeobox transcription factor that plays a critical role in embryonic development, particularly in craniofacial morphogenesis. ALX1 regulates gene expression involved in mesenchymal cell differentiation and skeletal development. Mutations in ALX1 are associated with frontonasal dysplasia (FND), a congenital disorder characterized by craniofacial anomalies such as cleft palate, wide nasal bridge, and abnormal eye positioning (hypertelorism). ALX1 is essential for the proper formation of facial structures during early development, as it influences neural crest cell migration and differentiation into facial mesenchyme. Beyond craniofacial development, ALX1 has been implicated in limb and organ patterning. Dysregulation of ALX1 may result in developmental abnormalities, highlighting its importance as a key regulator of embryogenesis. Recent studies suggest ALX1 may also be involved in tissue regeneration and mesenchymal stem cell maintenance, broadening its functional significance.
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