Alpha-Methylacyl-CoA Racemase (AMACR) Antibody

Este producto es parte de AMACR - Alpha-methylacyl-CoA racemase
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Alpha-Methylacyl-CoA Racemase (AMACR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx038238
tested applications
ELISA, WB

Description

Rabbit Polyclonal against the AMACR protein.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAlpha-Methylacyl-CoA Racemase (AMACR)
HostRabbit
ReactivityHuman
Recommended DilutionELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by Protein A/G column chromatography.
Size 1100 µg
Size 21 mg
FormLyophilized
Tested ApplicationsELISA, WB
BufferPrior to lyophilization: 0.02% NaN3.
AvailabilityShipped within 7-15 working days.
StorageStore at -20 °C. Avoid repeated freeze/thaw cycles.
Dry IceNo
NCBI AccessionNM_014324
AliasAMACR
BackgroundAntibody anti-AMACR
StatusRUO
NoteConcentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. -

Alpha-Methylacyl-CoA Racemase (AMACR) is a mitochondrial and peroxisomal enzyme that catalyzes the racemization of alpha-methyl-branched fatty acid derivatives and bile acid intermediates, enabling their further metabolism via beta-oxidation. AMACR is critical in lipid metabolism, particularly in the breakdown of dietary branched-chain fatty acids and the processing of bile acids derived from cholesterol. It is highly expressed in tissues with active fatty acid metabolism, such as the liver and kidneys. Dysregulation or mutations in the AMACR gene are associated with metabolic disorders, including adult-onset sensory neuropathy and bile acid metabolism defects. Additionally, AMACR is a well-established biomarker for prostate cancer and other malignancies, as its overexpression is linked to cancer cell metabolism and tumor progression. Targeting AMACR enzymatic activity is being explored as a therapeutic strategy in cancer and metabolic disorders.

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