Alpha-Methylacyl-CoA Racemase (AMACR) Antibody
286€ (40 µl)
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Name
Alpha-Methylacyl-CoA Racemase (AMACR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx227135
Tested Applications
IHC
Description
Alpha-Methylacyl-CoA Racemase (AMACR) Antibody is a Rabbit Monoclonal antibody for the detection of P504S (AMACR).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alpha-Methylacyl-CoA Racemase (AMACR) Immunogen: Synthetic peptide derived from the N-terminal region of human P504S. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC-P: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Clone ID | P495 |
| Purification | Purified from rabbit antiserum by proprietary techniques. |
| Size 1 | 40 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 500 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 20 mM Tris-HCl, pH 8.0, containing 20 mg/ml BSA and 0.05% NaN3. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 2-8°C. |
| Dry Ice | No |
| UniProt ID | Q9UHK6 |
| Alias | AMACR |
| Background | Antibody anti-AMACR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Alpha-Methylacyl-CoA Racemase (AMACR) is a mitochondrial and peroxisomal enzyme that catalyzes the racemization of alpha-methyl-branched fatty acid derivatives and bile acid intermediates, enabling their further metabolism via beta-oxidation. AMACR is critical in lipid metabolism, particularly in the breakdown of dietary branched-chain fatty acids and the processing of bile acids derived from cholesterol. It is highly expressed in tissues with active fatty acid metabolism, such as the liver and kidneys. Dysregulation or mutations in the AMACR gene are associated with metabolic disorders, including adult-onset sensory neuropathy and bile acid metabolism defects. Additionally, AMACR is a well-established biomarker for prostate cancer and other malignancies, as its overexpression is linked to cancer cell metabolism and tumor progression. Targeting AMACR enzymatic activity is being explored as a therapeutic strategy in cancer and metabolic disorders.
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